Thank you! I checked out your blog and gotta say I like your adventures too. :) But yeah, absolutely!
Of course Yosemite has a special place in my heart so if you can manage to drive up from Wawona through Tuolumne Meadows I’d suggest doing that up to Lake Tahoe! I’d say that would make the drive entirely worthwhile.
I’d say go as far up the 101 as humanly possible. Humboldt County has Fern Canyon (which, I don’t know if you know this, but it’s where Jurassic Park was filmed). Then switch on over to the 99 Redwood Highway and make sure you see the Avenue of the Giants! I’m afraid when I drove up I was way too rushed but I’d definitely suggest you take the detour and stop by Crater Lake. Maybe cruise up through the Columbia River Gorge and see Multnomah Falls too.
Up towards Washington there’s also Mount St. Helens, Vance Creek Bridge over in the Olympic National Forest, and of course the Big Four Ice Caves in the Mt. Baker-Snoqualmie National Forest.
Basically if you manage to avoid the 5 you’ll end up seeing a lot more worthwhile sights than if you rush up. I took way too long driving up because I like to just stop by and sit next to a river for awhile.
Let me know if you stop by Portland at all. Safe travels!